I am headed to PNG in a couple of weeks. Based on research from Wetpixel as well as other places. It seems Malerone is the most popular malaria prevention. However, my wife went to the doctor yesterday and he refused to prescribe it based on side effects. It seems that with a lot of people it can cause depression not just while you are on it, but long term. Anyone else had issues with this? He has instead prescribed Doxycycline. Which is still on the approved list for malaria from the CDC.