Tom, just remember your DOF will be VERY limited using the Subsee (even the 5+), so think about increasing you ISO so that you can use a bit tighter aperture.
That defeats the purpose. Any resolution you gained by getting closer is lost to diffraction and increased noise. It just ups the masochism factor, loses useful field of view, and does not show extra detail you couldn't have seen by cropping an image shot without diopter from a bit greater distance (the only exception being if you are in low viz conditions where just getting closer is a big benefit, but you could do that be selecting a shorter focal length lens).
There is nothing wrong in general with trading increased depth-of-field for lower spatial resolution by closing the aperture, except when your primary objective is to maximize the level of detail, then you want the image resolution to be at least close to the max sensor resolution.